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Integrating chemistry, molecular biology and experimental oncology

 2024

D. Yan, J. Arakelyan, T. Wan, R. Raina, T. K. Chan, D. Ahn, V. Kushnarev, T. K. Cheung, H. C. Chan, I. Choi, P. Y. Ho, F. Hu, Y. Kim, H. L. Lau, Y. L. Law, C. S. Leung, C. Y. Tong, K. K. Wong, W. L. Yim, R. Y.C. Kong*, M. V. Babak*, Y. Matsuda*, Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin: Creation of an unnatural analogue with improved anticancer properties, Acta Pharmaceutica Sinica B, 14(1), 421-432, 2024 (Q1, IF = 14.907)

 2023

J. Hoveyan, E. Asatryan, H. Grigoryan, S. Hovsepyan, A. Avagyan, L. Hakobyan, L. Sargsyan, S. Iskanyan, M. Avagyan, S. Hovhannisyan, I. Melnichenko, M. Minasyan, R. Papyan, N. Manukyan, A. Lazaryan, S. Danelyan, A. Muradyan, J. Arakelyan, I. Qaddoumi, F. Boop, A. Mkhitharyan, M. Harutyunyan, G. Tamamyan, S. Bardakhchyan, Trends in pediatric CNS tumors in Armenia: a multicenter retrospective study, Childs Nerv Syst, Volume 40, pages 435-444, 2023 (Q2, IF = 1.400)

R. P. Gale*, A. Muradyan, S. Danelyan, N. Manukyan, M. V. Babak, S. Arakelyan, G. Tamamyan, J. Arakelyan, The humanitarian crisis in Nagorno-Karabakh, The Lancet, 402(10410), 1324-1325, 2023 (Q1, IF = 168.9)

P.A. Egorov, D.A. Grishanov, A.G. Medvedev, A.V. Churakov, A.A. Mikhaylov, R. V. Ottenbacher, K  P. Bryliakov*, M. V. Babak*, O. Lev, P.V. Prikhodchenko*, Organoantimony Dihydroperoxides: Synthesis, Crystal Structures, and Hydrogen Bonding Networks, Inorganic Chemistry, 62(25), 9912-9923, 2023 (Q1, IF = 5.436)

Y. M. Ohorodnik, D. M. Khomenko*, R. O. Doroshchuk, I. V. Raspertova, S. Shova, M. V. Babak, M. NM. Milunovic, R. D. Lampeka, Synthesis, characterization and antiproliferative activity of platinum (II) complexes with 3-(2-pyridyl)-N1, 2-methyl-1, 2, 4-triazoles, Inorganica Chimica Acta, 556, 121646, 2023 (Q2, IF = 3.118)

V. I. Komlyagina, N. F. Romashev, V. K. Besprozvannykh, J. Arakelyan, C. Wu, A. S. Chubarov, I. V Bakaev, Y. K. Soh, P. A. Abramov, K. L. Cheung, N. B Kompan’kov, A. A. Ryadun, M. V. Babak*, A. L Gushchin*, Effects of Bis (imino) acenaphthene (Bian)-Derived Ligands on the Cytotoxicity, DNA Interactions, and Redox Activity of Palladium (II) Bipyridine Complexes, Inorganic Chemistry, 62(29), 11541-11553, 2023 (Q1, IF = 5.436)

S. M. Alfadul˜, E. M. Matnurov˜, A. E. Varakutin, M. V. Babak*, Metal-Based Anticancer Complexes and p53: How Much Do We Know? Cancers, 15(10), 2834, 2023 (Q1, IF 6.921)

J. Arakelyan, D. A. Rusanov, M. R. Chang, A. V. Asaturova, G. S. Kireeva, M. Alshehri, W. H. Ang, M. V. Babak*, Targeting emerging cancer hallmarks by transition metal complexes: Epigenetic reprogramming and epitherapies. Part II, Coordination Chemistry Reviews, 475, 214899, 2023 (Q1, IF 24.833)

M. R. Chang, D. A. Rusanov, J. Arakelyan, M. Alshehri, A. V. Asaturova, G. S. Kireeva, M. V. Babak*, W. H. Ang, Targeting emerging cancer hallmarks by transition metal complexes: Cancer stem cells and tumor microbiome. Part I, Coordination Chemistry Reviews, 477, 214899, 2023 (Q1, IF 24.833)

S. Nikolić, J. Arakelyan, V. Kushnarev, S. Mutasim Alfadul, D. Stanković, Y. I. Kraynik, S. Grgurić-Šipka, M. V. Babak, Coordination of Ru(II)-Arene Fragments to Dipyridophenazine Ligands Leads to the Modulation of Their In Vitro and In Vivo Anticancer Activity, Inorganic Chemistry, 62(21), 8188-8199, 2023 (Q1, IF 5.436)

D. A. Rusanov, S. Mutasim Alfadul, E. Yu. Portnyagina, E. A. Silyanova, N. A. Kuznetsov, K. E. Podpovetny, A. V. Samet, V. V. Semenov, M. V. Babak*Toward “E-Ring-Free” Lamellarin Analogues: Synthesis and Preliminary Biological Evaluation, ChemBioChem, e202300161, 2023 (Q1, IF 3.468)

 2022

A. Kamalyan, Y. Margaryan, J. Arakelyan, L. Safaryan, G. Tamamyan*, S. Arakelyan, Cancer and Armed Conflict: Crossing Realities, Journal of Clinical Oncology, 40(27), 3222-322, 2022 (Q1, IF 50.717)

D. A. Rusanov, J. Zou, M. V. Babak*. Biological properties of transition metal complexes with metformin and its analogues. Pharmaceuticals, 15(4), 453, 2022 (Q2, IF 5.215)

Y.M. Ohorodnik, S.A. Alexander, D.M. Khomenko, R.O. Doroshchuk, I.V. Raspertova, S. Shova*, M.V. Babak, R.D. Lampeka*. Synthesis, structural characterization and anticancer properties of p-cymene Ru(II) complexes with 2-(N-methyl-1H-1,2,4-triazol-3-yl)pyridines, Transition Metal Chemistry, in press, 2022 (Q2, IF 2.266) 

I. Kuznetcova, F. Bacher˜, S.M. Alfadul˜, M.J.R. Tham, W.H. Ang, M.V. Babak*, P. Rapta, V.B. Arion.* Elucidation of structure-activity relationships in indolobenzazepine-derived ligands and their copper(II) complexes: the role of key structural components and insight into the mechanism of action, Inorganic Chemistry, 61(26), 10167–10181, 2022 (Q1, IF 5.436)

D.A. Rusanov, J. Zou, M.V. Babak*. Biological Properties of Transition Metal Complexes with Metformin and Its Analogues, Pharmaceuticals, 15(4), 453, 2022 (Q1, IF 5.215)

N.F. Romashev, P.A. Abramov, I.V. Bakaev, I.S. Fomenko, D.G. Samsonenko, A.S. Novikov, K.K.H. Tong, D. Ahn, P.V. Dorovatovskii, Y.V. Zubavichus, A.A. Ryadun, O.A. Patutina, M.N. Sokolov, M.V. Babak,* A.L. Gushchin.* Heteroleptic Pd(II) and Pt(II) Complexes with Redox-Active Ligands: Synthesis, Structure, and Multimodal Anticancer Mechanism, Inorganic Chemistry, 61(4), 2105–2118, 2022 (Q1, IF 5.436)

C. Wittmann, A. S. Sivchenko, F. Bacher, K. K. H. Tong, N. Guru, T. Wilson, J. Gonzales, H. Rauch, S. Kossatz, T. Reiner*, M. V. Babak*, V. B. Arion* Inhibition of Microtubule Dynamics in Cancer Cells by Indole-Modified Latonduine Derivatives and Their Metal Complexes, Inorganic Chemistry, 1(3), 1456-1470, 2022 (Q1, IF 5.436) 

 2021

I. Stepanenko, M. V. Babak, G. Spengler, M. Hammerstad, A. Popovic-Bijelic, S. Shova, G. E. Büchel, D. Darvasiova, P. Rapta, V. B. Arion*. Coumarin-Based Triapine Derivatives and Their Copper(II) Complexes: Synthesis, Cytotoxicity and mR2 RNR Inhibition Activity, Biomolecules, 11 (6), 862, 2021 (Q2, IF 6.064)

 M.V. Babak,* K.R. Chong, P. Rapta, M. Zannikou, H.M. Tang, L. Reichert, M.R. Chang, V. Kushnarev, P. Heffeter, S.M. Meier-Menches, Z.C. Lim, J.Y. Yap, A. Casini, I.V. Balyasnikova, W.H. Ang.* Interfering with Metabolic Profile of Triple Negative Breast Cancers Using Rationally-Designed Metformin Prodrugs, Angewandte Chemie Int. Ed., 60 (24), 13405 - 13413, 2021 (Q1, IF 16.823)

A. Osypenko, A. Ashraf, V. Pozhydaiev, M.V. Babak, M. Hanif.* Organometallic Chemistry of Anticancer Ruthenium and Osmium Complexes, Comprehensive Organometallic Chemistry IV, Reference Collection in Chemistry, Molecular Science and Chemical Engineering, Oxford: Elsevier, 2021 (book chapter)

 2020

M.J.R. Tham, M.V. Babak,* W.H. Ang.* PlatinER: A Highly Potent Anticancer Platinum(II) complex that Induces Endoplasmic Reticulum Stress-Driven Immunogenic Cell Death, Angewandte Chemie Int. Ed., 59 (43), 19070-19078, 2020 (frontispiece) (Q1,  IF 16.823)

G. Kim, H.L. Tan, R. Sundar, B. Lieske, C.E. Chee, J. Ho, A. Shabbir, M.V. Babak, W.H. Ang, B.C. Goh, W.P. Yong,* L. Wang, J.B. So.* PIPAC-OX: A Phase I study of Oxaliplatin-based Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) in Patients with Peritoneal Metastases, Clinical Cancer Research, 27 (7), 1875-1881, 2020 (Q1,  IF 13.801)

M.V. Babak,* P.L. Faouder, X. Trivelli, G. Venkatesan, S.I. Bezzubov, M. Kajjout, O. Poizat, H. Vezin, C. Rolando. Heteroleptic ruthenium(II) complexes with bathophenanthroline and bathophenanthroline disulfonate disodium salt as fluorescent dyes for in-gel protein staining, Inorganic Chemistry, 59 (7), 4527-4535, 2020 (Q1, IF 5.436)

M.V. Babak, M.R. Zalutsky, I.V. Balyasnikova.* Heterogeneity and vascular permeability of breast cancer brain metastases, Cancer letters, 489, 174-181, 2020 (Q1, IF 9.756)

K. Ohui, I. Stepanenko,* I. Besleaga, M.V. Babak, R. Stafi, D. Darvasiova, G. Giester, V. Pósa, E.A. Enyedy, D. Vegh, P. Rapta, W.H. Ang, A. Popović-Bijelić, V. B Arion.* Triapine Derivatives Act as Copper Delivery Vehicles to Induce Deadly Metal Overload in Cancer Cells, Biomolecules 10 (9), 1336, 2020 (Q2, IF 6.064)

H.V. Le,≠ M.V. Babak,≠ M.A. Ehsan, M. Altaf, L. Reichert, A.L. Gushchin, W.H. Ang,* A.A. Isab.* Highly cytotoxic gold(I)-phosphane dithiocarbamate complexes trigger an ER stress-dependent immune response in ovarian cancer cells, Dalton Transactions 49 (22), 7355-7363,  2020 (Q1, IF 4.569)

 2019

M. V. Babak, Y. Zhi, B. Czarny, T.B. Toh, L. Hooi, E. K.-H. Chow, W.H. Ang,* D. Gibson,* G. Pastorin.* Dual-targeting Dual-action Platinum (IV) Platform for Enhanced Anticancer Activity and Reduced Nephrotoxicity, Angewandte Chemie Int. Ed., 58, 1-7, 2019 (Q1, IF 16.823)

L. Lungu, A. Ciocarlan, A. Barba, S. Shova, S. Pogrebnoi, I. Mangalagiu, C. Moldoveanu, N. Vornicu, M. D’Ambrosio,* M.V. Babak, V. B. Arion, A. Aricu. Synthesis and Evaluation of Biological Activity of Homodrimane Sesquiterpenoids Bearing Hydrazinecarbothioamide or 1,2,4-Triazole Unit, Chemistry of Heterocyclic Compounds 55 (8), 716-724, 2019 (Q4, IF 1.490)

K. Ohui, M.V. Babak, D. Darvasiova, A. Roller, D. Vegh, P. Rapta, G.R.S. Guan, Y.H. Ou, G. Pastorin, V.B. Arion.* Redox-Active Organoruthenium(II)– and Organoosmium(II)–Copper(II) Complexes, with an Amidrazone–Morpholine Hybrid and [CuICl2]− as Counteranion and Their Antiproliferative Activity, Organometallics 38 (10), 2307-2318,  2019 (Q2, IF 3.837)

A. Tan, M.V. Babak, G. Venkatesan, C. Lim, K.N. Klotz, D.R. Herr, S.L. Cheong, S. Federico, G. Spalluto, W.-Y. Ong, Y. Z. Chen, J. S. E. Loo, G. Pastorin.* Design, Synthesis and Evaluation of New Indolylpyrimidylpiperazines for Gastrointestinal Cancer Therapy, Molecules 24 (20), 3661, 2019 (Q2, IF 4.927)

K. Ohui, E. Afanasenko, F. Bacher, R.L.X. Ting, A. Zafar, O. Dömötör, D. Darvasiova, É.A. Enyedy, A. Popović-Bijelić, J. Reynisson, P. Rapta, M.V. Babak,* G. Pastorin, V.B. Arion.* New Water-Soluble Copper(II) Complexes with Morpholine-Thiosemicarbazone Hybrids: Insights into the Anticancer and Antibacterial Mode of Action, Journal of Medicinal Chemistry, 62(2), 512-530, 2019, (cover picture) (Q1, IF 8.039)

 2018

M.V. Babak,* M. Pfaffeneder-Kmen, S.M. Meier-Menches, M.S. Legina, S. Theiner, C. Licona, C. Orvain, M. Hejl, M. Hanif, M.A. Jacupec, B.K. Keppler, C. Gaiddon, C.G. Hartinger.* Rollover Cyclometalated Bipyridine Platinum Complexes as Potent Anticancer Agents: Impact of the Ancillary Ligands on the Mode of Action, Inorganic Chemistry, 57(5), 2851-2864, 2018 (Q1, IF 5.436)

M. J. Chow, M.V. Babak, K.W. Tan, M.C. Cheong, G. Pastorin, C. Gaiddon, W.H. Ang.* Induction of the Endoplasmic Reticulum Stress Pathway by Highly Cytotoxic Organoruthenium Schiff-Base Complexes, Molecular Pharmaceutics, 15, 3020-3031, 2018 (Q1, IF 5.364)

E. Orlowska, M.V. Babak, O. Domotor, E.A. Enyedy, P. Rapta, M. Zalibera, L. Bucinsky, M. Malcek, C. Govind, V. Karunakaran, D. Luneau, D. Schaniel, W. H. Ang, V. B. Arion.* NO releasing and Anticancer Properties of Octahedral Ruthenium-Nitrosyl Complexes with Equatorial 1H-Indazole Ligands, Inorganic Chemistry, 57(17), 10702-10717, 2018 (Q1, IF 5.436)

N.Y.S. Lam, D. Truong, H. Burmeister, M.V. Babak, H.U. Holtkamp, S. Movassaghi, D.M. Aine-Tora, A. Zafar, M. Kubanik, L. Oehninger, T. Söhnel, J. Reynisson, S.M.F. Jamieson, C. Gaiddon, I. Ott, C. Hartinger.* From Catalysis to Cancer: Toward Structure-Activity Relationships for Benzymidazol-2-ylidene-Derived N-heterocyclic Carbene Complexes as Anticancer Agents, Inorganic Chemistry, 57(22), 14427-14434, ,2018 (Q1, IF 5.436)

K.G.Z. Lee, M.V. Babak, A. Weiss, P.J. Dyson, P. Nowak-Sliwinska,* D. Montagner,* W. H. Ang.* Development of an Efficient Dual-​Action GST-​Inhibiting Anticancer Platinum(IV) Prodrug, ChemMedChem, 13(12), 1210-1217, 2018 (Q2, IF 3.540)

S. De, M.V. Babak, M.J. Huelsey, W.H. Ang,* N. Yang.* Designed Precursor for the Controlled Synthesis of Highly Active Atomic and Sub-​nanometric Platinum Catalysts on Mesoporous Silica, Chemistry – An Asian Journal, 13(8), 1053-1059, 2018 (Q2, IF 4.839) 

S. P. Gavrish, Y. D. Lampeka,* M. V. Babak, V. B. Arion. Palladium Complexes of N,​N'-​Bis(2-​aminoethyl)​oxamide (H2L)​: Structural (PdIIL, PdII2L2, and PdIVLCl2)​, Electrochemical, Dynamic 1H NMR, and Cytotoxicity Studies, Inorganic Chemistry, 57(3), 1288-1297, 2018 (Q1, IF 5.436)

M. V. Babak, W. H. Ang, Multinuclear Organometallic Ruthenium-Arene complexes for Cancer Therapy, in Metallo-Drugs: Development and Action of Anticancer Agents, Vol. 18 of Metal Ions in Life Sciences, ed. by A. Sigel, H. Sigel, E. Freisinger, R. K. O. Sigel, Walter de Gruyter, GmbH, Berlin, Germany, 171-198, 2018, ISBN: 978-3-11-046984-4 (book chapter)

 2017

A. Sirbu, O. Palamarciuc, M.V. Babak,* J.M. Lim, K. Ohui, E.A. Enyedy, S. Shova, D. Darvasiova, P. Rapta, W.H. Ang,* V.B. Arion.* Copper(II) Thiosemicarbazone Complexes Induce Marked ROS Accumulation and Promote Nrf2-mediated Antioxidant Response in Highly Resistant Breast Cancer Cells, Dalton Transactions, 46, 3833-3847, 2017 (cover picture) (Q1, IF 4.569) 

2016

C. Muller, M.V. Babak, M. Kubanik, M. Hanif, S.M.F. Jamieson, C.G. Hartinger,* J.L. Wright,* Pt(II) Pyridinium Amidate (PYA) Complexes: Preparation and In Vitro Anticancer Activity Studies, Inorganica Chimica Acta, 450, 124-130, 2016 (Q1, IF 3.118)

M.J. Chow, M.V. Babak, D.Y.Q. Wong, G. Pastorin, C. Gaiddon, W.H. Ang.* Structural Determinants of p53-Independence in Anticancer Ruthenium-Arene Schiff-Base Complexes, Molecular Pharmaceutics, 13, 2543-2554, 2016 (Q1, IF 5.364)

B.S. Murray, M.V. Babak, C.G. Hartinger,* P.J. Dyson.* The Development of RAPTA-compounds in the Treatment of Tumors, Coordination Chemistry Reviews, 306 (Part 1), 86-114, 2016 (Q1, IF 24.833)

 2015

M.V. Babak, S.M. Meier, K. V. Huber, J. Reynisson, A.A. Legin, M.A. Jacupec, A. Roller, A. Stukalov, M. Gridling, K.L. Bennett, J. Colinge, W. Berger, P.J. Dyson, G. Superti-Furga, B.K. Keppler, C.G. Hartinger.* Target Profiling of an Antimetastatic RAPTA Agent by Chemical Proteomics: Relevance to the Mode of Action, Chemical Science, 6(4), 2449-2456, 2015 (Q1, IF 9.969)

M.V. Babak, D. Plazuk, S.M. Meier, J.H. Arabschahi, J. Reynisson, B. Rychlik, A. Blauz, K. Szulc, M. Hanif, S. Strobl, B.K. Keppler, C.G. Hartinger.* Half-Sandwich Ruthenium(II) Biotin-Conjugates as Biological Vectors to Cancer Cells, Chemistry – A European Journal, 21(13), 5110-5117, 2015 (Q1, IF 5.020) 

M.V. Babak, M. Airey, C.G. Hartinger, Metal Compounds as Kinase and Phosphatase Inhibitors in Drug Development: The Role of the Metal and Ligands, Chapter 13, Kinomics: Approaches and applications, ed. by H.-B. Kraatz, S. Martic, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, 301-329, 2015, ISBN: 978-3-527-33765-1 (book chapter)

 2014

M. Hanif,* M.A.H. Nawaz, M.V. Babak, J. Iqbal, A. Roller, B.K. Keppler, C.G. Hartinger.* Ruthenium(II)(η6-arene) Complexes of Thiourea Derivatives: Synthesis, Characterization and Urease Inhibition, Molecules, 19(6), 8080-8092, 2014 (Q2, IF 4.927)

S.M. Meier, M.V. Babak, B.K. Keppler, C.G. Hartinger.* Efficiently Detecting Metallodrug-Protein Adducts: Ion Trap versus Time-of-Flight Mass Analyzers, ChemMedChem, 9(7), 1351-1355, 2014 (Q2, IF 3.540) 

 2013

M.V. Babak, S.M. Meier, A.A. Legin, M.S.A. Razavi, A. Roller, M.A. Jacupec, B.K. Keppler, Christian G. Hartinger.* Am(m)ines Make the Difference: Organometallic Ru(ammine) Complexes and Their Chemistry in Anticancer Drug Development, Chemistry – A European Journal, 19(13), 4308-4318, 2013 (Q1, IF 5.020)

 2012

D.S. Perekalin, M.V. Babak, E.E. Karslyan, Y.V. Nelyubina, A.R. Kudinov.* Synthesis and Reactivity of Iron Complexes [(η5-Indenyl)MFeL3]+ from the Readily Available (η5-Indenyl)Fe(η6-Indene)]+, Inorganica Chimica Acta, 392, 73-76, 2012 (Q2, IF 3.118)

 2011

D.S. Perekalin, M.V. Babak, V.V. Novikov, P.V. Petrovskii, K.A. Lyssenko, A.R. Kudinov.* (Mesitylene)ruthenium π-Complexes with Benzo-15-crown-5 and Dibenzo-18-crown-6, Journal of Organometallic Chemistry, 695(8), 1200-1204, 2010 (Q2, IF 2.345)

 2007

D.S. Perekalin, M.V. Babak, V.V. Novikov, P.V. Petrovskii, K.A. Lyssenko, M. Corsini, P. Zanello, A.R. Kudinov.* A New Approach to the Photochemically Controlled Crown Ethers: (Tetramethylcyclobutadiene)cobalt Complexes with Benzo-15-crown-5 and Dibenzo-18-crown-6, Organometallics, 27(15), 3654-3658, 2007 (Q2, IF 3.837)