Integrating chemistry, molecular biology and experimental oncology

Journal Club

The purpose of the Journal Club is to not only broaden knowledge but also to investigate on the research design of the papers from high impact journals.

11 April - Chengnan Wu Andy

Article information:

Fromont, C., Atzori, A., Kaur, D., Hashmi, L., Greco, G., Cabanillas, A., Nguyen, H. V., Jones, D. H., Garzón, M., Varela, A., Stevenson, B., Iacobini, G. P., Lenoir, M., Rajesh, S., Box, C., Kumar, J., Grant, P., Novitskaya, V., Morgan, J., Sorrell, F. J., … Butterworth, S. (2020). Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity in Vivo Mouse Model. Journal of medicinal chemistry, 63(13), 6784–6801. https://doi.org/10.1021/acs.jmedchem.9b01803

Reviewed by Andy Wu

4 April - Ahn Dohyun

Article Information

Zhang, J. J., Ng, K. M., Lok, C. N., Sun, R. W., & Che, C. M. (2013). Deubiquitinases as potential anti-cancer targets for gold(III) complexes. Chemical communications (Cambridge, England), 49(45), 5153–5155. https://doi.org/10.1039/c3cc41766b

Reviewed by Ahn Dohyun

25 March - Reviewed by Samah

Article Information

Huang Y, Yuan K, Tang M, et al. Melatonin inhibiting the survival of human gastric cancer cells under ER stress involving autophagy and Ras-Raf-MAPK signalling. J Cell Mol Med. 2021;25(3):1480-1492. doi:10.1111/jcmm.16237

Reviewed by Samah Mutaism

18 March - Jemma Arakelyan

Article Information

Zhang, J., Jiang, M., Li, S., Zhang, Z., Sun, H., Yang, F., & Liang, H. (2021). Developing a Novel Anticancer Gold(III) Agent to Integrate Chemotherapy and Immunotherapy. Journal of medicinal chemistry, 64(10), 6777–6791. https://doi.org/10.1021/acs.jmedchem.1c00050

Reviewed by Jemma Arakelyan

11 March - Zhuolin Ye

Article information

Carcelli, M., Tegoni, M., Bartoli, J., Marzano, C., Pelosi, G., Salvalaio, M., Rogolino, D., & Gandin, V. (2020). In vitro and in vivo anticancer activity of tridentate thiosemicarbazone copper complexes: Unravelling an unexplored pharmacological target. European journal of medicinal chemistry, 194, 112266. https://doi.org/10.1016/j.ejmech.2020.112266

Reviewed by Zhuolin Ye

4 March - Ahn Dohyun

Article information:

Tham, M., Babak, M. V., & Ang, W. H. (2020). PlatinER: A Highly Potent Anticancer Platinum(II) Complex that Induces Endoplasmic Reticulum Stress Driven Immunogenic Cell Death. Angewandte Chemie (International ed. in English), 59(43), 19070–19078.

Reviewed by Ahn Dohyun

28 February - Samah

Article information
Ibrahim H. Eissa, Mohammed A. Dahab, Mohamed K. Ibrahim, Nawaf A. Alsaif, A.Z. Alanazi, Sally I. Eissa, Ahmed B.M. Mehany, André M. Beauchemin, Design and discovery of new antiproliferative 1,2,4-triazin-3(2H)-ones as tubulin polymerization inhibitors targeting colchicine binding site, Bioorganic Chemistry, Volume 112, 2021, 104965, ISSN 0045-2068, https://doi.org/10.1016/j.bioorg.2021.104965.

Reviewed by Samah Mutaism

 

14 February - Zhuolin Ye

Article information:

Cancer Cell Resistance Against the Clinically Investigated Thiosemicarbazone COTI-2 Is Based on Formation of Intracellular Copper Complex Glutathione Adducts and ABCC1-Mediated Efflux Julia H. Bormio Nunes, Sonja Hager, Marlene Mathuber, Vivien Pósa, Alexander Roller, Éva A. Enyedy, Alessia Stefanelli, Walter Berger, Bernhard K. Keppler, Petra Heffeter, and Christian R. Kowol Journal of Medicinal Chemistry 2020 63 (22), 13719-13732 DOI: 10.1021/acs.jmedchem.0c01277

Reviewed by Zhuolin Ye

 

21 January - Jemma

Article information:

Rationally Designed Redox-Active Au(I) N-Heterocyclic Carbene: An Immunogenic Cell Death Inducer Sajal Sen, Stephanie Hufnagel, Esther Y. Maier, Isaiah Aguilar, Jayaraman Selvakumar, Jennie E. DeVore, Vincent M. Lynch, Kuppuswamy Arumugam, Zhengrong Cui, Jonathan L. Sessler, and Jonathan F. Arambula Journal of the American Chemical Society 2020 142 (49), 20536-20541 DOI: 10.1021/jacs.0c09753

Reviewed by Jemma Arakelyan